Modeling of Rifampicin-Induced CYP3A4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data

Induction of cytochrome P450 3A4 (CYP3A4) expression is often implicated in clinically relevant drug-drug interactions (DDI), as metabolism catalyzed by this enzyme is the dominant route of elimination for many drugs. Although several DDI models have been proposed, none have comprehensively consider...

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Detalles Bibliográficos
Autores principales: Yamashita, Fumiyoshi, Sasa, Yukako, Yoshida, Shuya, Hisaka, Akihiro, Asai, Yoshiyuki, Kitano, Hiroaki, Hashida, Mitsuru, Suzuki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782498/
https://www.ncbi.nlm.nih.gov/pubmed/24086247
http://dx.doi.org/10.1371/journal.pone.0070330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782498/
https://www.ncbi.nlm.nih.gov/pubmed/24086247
http://dx.doi.org/10.1371/journal.pone.0070330

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