Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems

The glycosylation of recombinant β-glucocerebrosidase, and in particular the exposure of mannose residues, has been shown to be a key factor in the success of ERT (enzyme replacement therapy) for the treatment of GD (Gaucher disease). Macrophages, the target cells in GD, internalize β-glucocerebrosi...

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Detalles Bibliográficos
Autores principales: Tekoah, Yoram, Tzaban, Salit, Kizhner, Tali, Hainrichson, Mariana, Gantman, Anna, Golembo, Myriam, Aviezer, David, Shaaltiel, Yoseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782720/
https://www.ncbi.nlm.nih.gov/pubmed/23980545
http://dx.doi.org/10.1042/BSR20130081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782720/
https://www.ncbi.nlm.nih.gov/pubmed/23980545
http://dx.doi.org/10.1042/BSR20130081

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