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Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems
The glycosylation of recombinant β-glucocerebrosidase, and in particular the exposure of mannose residues, has been shown to be a key factor in the success of ERT (enzyme replacement therapy) for the treatment of GD (Gaucher disease). Macrophages, the target cells in GD, internalize β-glucocerebrosi...
Autores principales: | Tekoah, Yoram, Tzaban, Salit, Kizhner, Tali, Hainrichson, Mariana, Gantman, Anna, Golembo, Myriam, Aviezer, David, Shaaltiel, Yoseph |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782720/ https://www.ncbi.nlm.nih.gov/pubmed/23980545 http://dx.doi.org/10.1042/BSR20130081 |
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