Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines

Various anticancer drugs, including camptothecins and indolocarbazoles, target DNA topoisomerase I (Top1). We previously described the camptothecin-resistant colon cancer cell line DLDSNR6, which has a Gly365Ser missense mutation in Top1. In the present study, we established highly camptothecin-resi...

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Detalles Bibliográficos
Autores principales: ARAKAWA, YASUHIRO, OZAKI, KOJI, OKAWA, YUTAKA, YAMADA, HISASHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783056/
https://www.ncbi.nlm.nih.gov/pubmed/23836376
http://dx.doi.org/10.3892/or.2013.2594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783056/
https://www.ncbi.nlm.nih.gov/pubmed/23836376
http://dx.doi.org/10.3892/or.2013.2594

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