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Unique structural properties associated with mouse prion Δ105–125 protein
Murine prion protein deleted for residues 105–125 is intrinsically neurotoxic and mediates a TSE-like phenotype in transgenic mice. Equivalent and overlapping deletions were expressed in E.coli, purified and analyzed. Among mutants spanning the region 95–135, a construct lacking solely residues 105–...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783109/ https://www.ncbi.nlm.nih.gov/pubmed/23764837 http://dx.doi.org/10.4161/pri.24429 |