Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion

The p53 core domain binds to response elements (REs) that contain two continuous half-sites as a cooperative tetramer, but how p53 recognizes discontinuous REs is not well understood. Here we describe the crystal structure of the p53 core domain bound to a naturally occurring RE located at the promo...

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Detalles Bibliográficos
Autores principales: Chen, Yongheng, Zhang, Xiaojun, Dantas Machado, Ana Carolina, Ding, Yuan, Chen, Zhuchu, Qin, Peter Z., Rohs, Remo, Chen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783167/
https://www.ncbi.nlm.nih.gov/pubmed/23836939
http://dx.doi.org/10.1093/nar/gkt584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783167/
https://www.ncbi.nlm.nih.gov/pubmed/23836939
http://dx.doi.org/10.1093/nar/gkt584

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