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Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
The p53 core domain binds to response elements (REs) that contain two continuous half-sites as a cooperative tetramer, but how p53 recognizes discontinuous REs is not well understood. Here we describe the crystal structure of the p53 core domain bound to a naturally occurring RE located at the promo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783167/ https://www.ncbi.nlm.nih.gov/pubmed/23836939 http://dx.doi.org/10.1093/nar/gkt584 |