Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

Influenza virus uses a unique cap-snatching mechanism characterized by hijacking and cleavage of host capped pre-mRNAs, resulting in short capped RNAs, which are used as primers for viral mRNA synthesis. The PA subunit of influenza polymerase carries the endonuclease activity that catalyzes the host...

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Detalles Bibliográficos
Autores principales: Datta, Kausiki, Wolkerstorfer, Andrea, Szolar, Oliver H. J., Cusack, Stephen, Klumpp, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783182/
https://www.ncbi.nlm.nih.gov/pubmed/23847103
http://dx.doi.org/10.1093/nar/gkt603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783182/
https://www.ncbi.nlm.nih.gov/pubmed/23847103
http://dx.doi.org/10.1093/nar/gkt603

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