Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK

Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammatory conditions, the molecular mechanisms underlying...

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Detalles Bibliográficos
Autores principales: Nomura, Johji, Busso, Nathalie, Ives, Annette, Tsujimoto, Syunsuke, Tamura, Mizuho, So, Alexander, Yamanaka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783396/
https://www.ncbi.nlm.nih.gov/pubmed/24086554
http://dx.doi.org/10.1371/journal.pone.0075527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783396/
https://www.ncbi.nlm.nih.gov/pubmed/24086554
http://dx.doi.org/10.1371/journal.pone.0075527

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