Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development

NADPH-cytochrome P450 oxidoreductase (POR) is the primary electron donor for cytochromes P450, dehydrocholesterol reductase, heme oxygenase, and squalene monooxygenase. Human patients with specific mutations in POR exhibit severe developmental malformations including disordered steroidogenesis, sexu...

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Detalles Bibliográficos
Autores principales: Panda, Satya P., Guntur, Anyonya R., Polusani, Srikanth R., Fajardo, Roberto J., Gakunga, Peter T., Roman, Linda J., Masters, Bettie Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783497/
https://www.ncbi.nlm.nih.gov/pubmed/24086598
http://dx.doi.org/10.1371/journal.pone.0075638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783497/
https://www.ncbi.nlm.nih.gov/pubmed/24086598
http://dx.doi.org/10.1371/journal.pone.0075638

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