Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate

Valproic acid (VPA) is widely used as an anti-epileptic drug. The primary mechanism of VPA toxicity is interference with mitochondrial beta-oxidation, and it can exacerbate an underlying mitochondrial cytopathy. We report a case of Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-...

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Autores principales: Chaudhry, Neera, Patidar, Yogesh, Puri, Vinod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783723/
https://www.ncbi.nlm.nih.gov/pubmed/24082934
http://dx.doi.org/10.4103/1817-1745.117847
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author Chaudhry, Neera
Patidar, Yogesh
Puri, Vinod
author_facet Chaudhry, Neera
Patidar, Yogesh
Puri, Vinod
author_sort Chaudhry, Neera
collection PubMed
description Valproic acid (VPA) is widely used as an anti-epileptic drug. The primary mechanism of VPA toxicity is interference with mitochondrial beta-oxidation, and it can exacerbate an underlying mitochondrial cytopathy. We report a case of Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unmasked by use of Sodium Valproate in a 12-year-old boy who presented with headache and seizures. There was precipitation of encephalopathy, myopathy, lactic acidosis, and hepatic damage within two days of valproate use, after withdrawing of which there was a remarkable clinical and biochemical recovery.
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spelling pubmed-37837232013-09-30 Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate Chaudhry, Neera Patidar, Yogesh Puri, Vinod J Pediatr Neurosci Case Report Valproic acid (VPA) is widely used as an anti-epileptic drug. The primary mechanism of VPA toxicity is interference with mitochondrial beta-oxidation, and it can exacerbate an underlying mitochondrial cytopathy. We report a case of Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unmasked by use of Sodium Valproate in a 12-year-old boy who presented with headache and seizures. There was precipitation of encephalopathy, myopathy, lactic acidosis, and hepatic damage within two days of valproate use, after withdrawing of which there was a remarkable clinical and biochemical recovery. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3783723/ /pubmed/24082934 http://dx.doi.org/10.4103/1817-1745.117847 Text en Copyright: © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chaudhry, Neera
Patidar, Yogesh
Puri, Vinod
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
title Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
title_full Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
title_fullStr Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
title_full_unstemmed Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
title_short Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
title_sort mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783723/
https://www.ncbi.nlm.nih.gov/pubmed/24082934
http://dx.doi.org/10.4103/1817-1745.117847
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AT patidaryogesh mitochondrialmyopathyencephalopathylacticacidosisandstrokelikeepisodesunveiledbyvalproate
AT purivinod mitochondrialmyopathyencephalopathylacticacidosisandstrokelikeepisodesunveiledbyvalproate

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