Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes

Indenoisoquinolines are the most promising non-campthotecins topoisomerase IB inhibitors. We present an integrated experimental/computational investigation of the UV-Vis spectra of the IQNs parental compound (NSC314622) and two of its derivatives (NSC724998 and NSC725776) currently undergoing Phase...

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Detalles Bibliográficos
Autores principales: Coletta, Andrea, Castelli, Silvia, Chillemi, Giovanni, Sanna, Nico, Cushman, Mark, Pommier, Yves, Desideri, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784438/
https://www.ncbi.nlm.nih.gov/pubmed/24086299
http://dx.doi.org/10.1371/journal.pone.0073881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784438/
https://www.ncbi.nlm.nih.gov/pubmed/24086299
http://dx.doi.org/10.1371/journal.pone.0073881

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