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Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes

Indenoisoquinolines are the most promising non-campthotecins topoisomerase IB inhibitors. We present an integrated experimental/computational investigation of the UV-Vis spectra of the IQNs parental compound (NSC314622) and two of its derivatives (NSC724998 and NSC725776) currently undergoing Phase...

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Detalles Bibliográficos
Autores principales:	Coletta, Andrea, Castelli, Silvia, Chillemi, Giovanni, Sanna, Nico, Cushman, Mark, Pommier, Yves, Desideri, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784438/ https://www.ncbi.nlm.nih.gov/pubmed/24086299 http://dx.doi.org/10.1371/journal.pone.0073881

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