Leu452His Mutation in Lipoprotein Lipase Gene Transfer Associated with Hypertriglyceridemia in Mice in vivo

Mutated mouse lipoprotein lipase (LPL) containing a leucine (L) to histidine (H) substitution at position 452 was transferred into mouse liver by hydrodynamics-based gene delivery (HD). Mutated-LPL (MLPL) gene transfer significantly increased the concentrations of plasma MLPL and triglyceride (TG) b...

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Detalles Bibliográficos
Autores principales: Sun, Kaiyue, Yang, Wei, Huang, Yanna, Wang, Yizhen, Xiang, Lan, Qi, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784453/
https://www.ncbi.nlm.nih.gov/pubmed/24086538
http://dx.doi.org/10.1371/journal.pone.0075462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784453/
https://www.ncbi.nlm.nih.gov/pubmed/24086538
http://dx.doi.org/10.1371/journal.pone.0075462

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