Inherited Prion Disease A117V Is Not Simply a Proteinopathy but Produces Prions Transmissible to Transgenic Mice Expressing Homologous Prion Protein

Prions are infectious agents causing fatal neurodegenerative diseases of humans and animals. In humans, these have sporadic, acquired and inherited aetiologies. The inherited prion diseases are caused by one of over 30 coding mutations in the human prion protein (PrP) gene (PRNP) and many of these g...

Descripción completa

Detalles Bibliográficos
Autores principales: Asante, Emmanuel A., Linehan, Jacqueline M., Smidak, Michelle, Tomlinson, Andrew, Grimshaw, Andrew, Jeelani, Asif, Jakubcova, Tatiana, Hamdan, Shyma, Powell, Caroline, Brandner, Sebastian, Wadsworth, Jonathan D. F., Collinge, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784465/
https://www.ncbi.nlm.nih.gov/pubmed/24086135
http://dx.doi.org/10.1371/journal.ppat.1003643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784465/
https://www.ncbi.nlm.nih.gov/pubmed/24086135
http://dx.doi.org/10.1371/journal.ppat.1003643

Ejemplares similares