Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

The broadly-neutralizing anti-HIV antibody 4E10 recognizes an epitope in the membrane-proximal external region of the HIV envelope protein gp41. Previous attempts to elicit 4E10 by vaccination with envelope-derived or reverse-engineered immunogens have failed. It was presumed that the ontogeny of 4E...

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Detalles Bibliográficos
Autores principales: Finton, Kathryn A. K., Larimore, Kevin, Larman, H. Benjamin, Friend, Della, Correnti, Colin, Rupert, Peter B., Elledge, Stephen J., Greenberg, Philip D., Strong, Roland K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784475/
https://www.ncbi.nlm.nih.gov/pubmed/24086134
http://dx.doi.org/10.1371/journal.ppat.1003639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784475/
https://www.ncbi.nlm.nih.gov/pubmed/24086134
http://dx.doi.org/10.1371/journal.ppat.1003639

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