Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations have historically been difficult to study because of technical limitations in accurately quantifying rare mtDNA mutations. We have...

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Detalles Bibliográficos
Autores principales: Kennedy, Scott R., Salk, Jesse J., Schmitt, Michael W., Loeb, Lawrence A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784509/
https://www.ncbi.nlm.nih.gov/pubmed/24086148
http://dx.doi.org/10.1371/journal.pgen.1003794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784509/
https://www.ncbi.nlm.nih.gov/pubmed/24086148
http://dx.doi.org/10.1371/journal.pgen.1003794

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