A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation

Wnt signaling, which encompasses multiple biochemical pathways that regulate neural development downstream of extracellular Wnt glycoprotein ligands, has been suggested to contribute to major psychiatric disorders including autism spectrum disorders (ASD). We used next-generation sequencing and Sequ...

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Detalles Bibliográficos
Autores principales: Martin, P-M, Yang, X, Robin, N, Lam, E, Rabinowitz, J S, Erdman, C A, Quinn, J, Weiss, L A, Hamilton, S P, Kwok, P-Y, Moon, R T, Cheyette, B N R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784764/
https://www.ncbi.nlm.nih.gov/pubmed/24002087
http://dx.doi.org/10.1038/tp.2013.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784764/
https://www.ncbi.nlm.nih.gov/pubmed/24002087
http://dx.doi.org/10.1038/tp.2013.75

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