Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose)

Single-strand breaks (SSBs) are the most common type of oxidative DNA damage and they are related to aging and many genetic diseases. The scaffold protein for repair of SSBs, XRCC1, accumulates at sites of poly(ADP-ribose) (pAR) synthesized by PARP, but it is retained at sites of SSBs after pAR degr...

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Detalles Bibliográficos
Autores principales: Wei, Leizhen, Nakajima, Satoshi, Hsieh, Ching-Lung, Kanno, Shinichiro, Masutani, Mitsuko, Levine, Arthur S., Yasui, Akira, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784821/
https://www.ncbi.nlm.nih.gov/pubmed/23868975
http://dx.doi.org/10.1242/jcs.128272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784821/
https://www.ncbi.nlm.nih.gov/pubmed/23868975
http://dx.doi.org/10.1242/jcs.128272

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