Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc

Antigen-binding Fc fragments (Fcab) are generated by engineering the C-terminal loop regions in the CH3 domain of human immunoglobulin G class 1-crystallizable fragment (IgG1-Fc). For an optimum library design with high percentage of well-folded clones for efficient binder selection, information abo...

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Detalles Bibliográficos
Autores principales: Hasenhindl, Christoph, Traxlmayr, Michael W., Wozniak-Knopp, Gordana, Jones, Phil C., Stadlmayr, Gerhard, Rüker, Florian, Obinger, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785252/
https://www.ncbi.nlm.nih.gov/pubmed/24006374
http://dx.doi.org/10.1093/protein/gzt041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785252/
https://www.ncbi.nlm.nih.gov/pubmed/24006374
http://dx.doi.org/10.1093/protein/gzt041

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