Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. The human muscle isozyme is significantly more sensitive towards the allosteric inhibitor, AMP, than the liver isoform. Here we report crystal structures and kinetic studies for wild-type human muscle F...

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Detalles Bibliográficos
Autores principales: Shi, Rong, Chen, Ze-Yong, Zhu, Dao-Wei, Li, Chunmin, Shan, Yufei, Xu, Genjun, Lin, Sheng-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785478/
https://www.ncbi.nlm.nih.gov/pubmed/24086250
http://dx.doi.org/10.1371/journal.pone.0071242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785478/
https://www.ncbi.nlm.nih.gov/pubmed/24086250
http://dx.doi.org/10.1371/journal.pone.0071242

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