Modeling the Conformational Changes Underlying Channel Opening in CFTR

Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator protein (CFTR) cause cystic fibrosis (CF), the most common life-shortening genetic disease among Caucasians. Although general features of the structure of CFTR have been predicted from homology models, the conform...

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Detalles Bibliográficos
Autores principales: Rahman, Kazi S., Cui, Guiying, Harvey, Stephen C., McCarty, Nael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785483/
https://www.ncbi.nlm.nih.gov/pubmed/24086355
http://dx.doi.org/10.1371/journal.pone.0074574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785483/
https://www.ncbi.nlm.nih.gov/pubmed/24086355
http://dx.doi.org/10.1371/journal.pone.0074574

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