Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on bortezomib-regulated cellular pathways. In the present study, we investigated CK2 expression in multiple myeloma and mantle cell lymphoma, two bortezomib-responsive B cell tumors, as well as its involvement i...

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Detalles Bibliográficos
Autores principales: Manni, Sabrina, Brancalion, Alessandra, Mandato, Elisa, Tubi, Laura Quotti, Colpo, Anna, Pizzi, Marco, Cappellesso, Rocco, Zaffino, Fortunato, Di Maggio, Speranza Antonia, Cabrelle, Anna, Marino, Filippo, Zambello, Renato, Trentin, Livio, Adami, Fausto, Gurrieri, Carmela, Semenzato, Gianpietro, Piazza, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785505/
https://www.ncbi.nlm.nih.gov/pubmed/24086494
http://dx.doi.org/10.1371/journal.pone.0075280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785505/
https://www.ncbi.nlm.nih.gov/pubmed/24086494
http://dx.doi.org/10.1371/journal.pone.0075280

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