The microtubule depolymerizing agent CYT997 effectively kills acute myeloid leukemia cells via activation of caspases and inhibition of PI3K/Akt/mTOR pathway proteins

The orally active microtubule-depolymerizing agent CYT997 is potently cytotoxic to a variety of tumors in vitro and in vivo. However, the effects of this agent on acute myeloid leukemia (AML) cells and its mechanisms are unknown. The present study demonstrated that CYT997 effectively inhibited the g...

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Detalles Bibliográficos
Autores principales: CHEN, XIAOHUI, YANG, CHUNMEI, XU, YANHUA, ZHOU, HUI, LIU, HUI, QIAN, WENBIN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786882/
https://www.ncbi.nlm.nih.gov/pubmed/24137178
http://dx.doi.org/10.3892/etm.2013.1161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786882/
https://www.ncbi.nlm.nih.gov/pubmed/24137178
http://dx.doi.org/10.3892/etm.2013.1161

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