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The microtubule depolymerizing agent CYT997 effectively kills acute myeloid leukemia cells via activation of caspases and inhibition of PI3K/Akt/mTOR pathway proteins
The orally active microtubule-depolymerizing agent CYT997 is potently cytotoxic to a variety of tumors in vitro and in vivo. However, the effects of this agent on acute myeloid leukemia (AML) cells and its mechanisms are unknown. The present study demonstrated that CYT997 effectively inhibited the g...
Autores principales: | CHEN, XIAOHUI, YANG, CHUNMEI, XU, YANHUA, ZHOU, HUI, LIU, HUI, QIAN, WENBIN |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786882/ https://www.ncbi.nlm.nih.gov/pubmed/24137178 http://dx.doi.org/10.3892/etm.2013.1161 |
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