Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

In mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg effects). However, because both nuclear DNA and mtD...

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Detalles Bibliográficos
Autores principales: Imanishi, Hirotake, Takibuchi, Gaku, Kobayashi, Toshihiko, Ishikawa, Kaori, Nakada, Kazuto, Mori, Masayuki, Kikkawa, Yoshiaki, Takenaga, Keizo, Toyama-Sorimachi, Noriko, Hayashi, Jun-Ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786894/
https://www.ncbi.nlm.nih.gov/pubmed/24098752
http://dx.doi.org/10.1371/journal.pone.0075981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786894/
https://www.ncbi.nlm.nih.gov/pubmed/24098752
http://dx.doi.org/10.1371/journal.pone.0075981

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