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Control of the Rescue and Replication of Semliki Forest Virus Recombinants by the Insertion of miRNA Target Sequences

Due to their broad cell- and tissue-tropism, alphavirus-based replication-competent vectors are of particular interest for anti-cancer therapy. These properties may, however, be potentially hazardous unless the virus infection is controlled. While the RNA genome of alphaviruses precludes the standar...

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Detalles Bibliográficos
Autores principales: Ratnik, Kaspar, Viru, Liane, Merits, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786945/
https://www.ncbi.nlm.nih.gov/pubmed/24098728
http://dx.doi.org/10.1371/journal.pone.0075802