Functionally Deregulated AML1/RUNX1 Cooperates with BCR-ABL to Induce a Blastic Phase-Like Phenotype of Chronic Myelogenous Leukemia in Mice

Patients in the chronic phase (CP) of chronic myelogenous leukemia (CML) have been treated successfully following the advent of ABL kinase inhibitors, but once they progress to the blast crisis (BC) phase the prognosis becomes dismal. Although mechanisms underlying the progression are largely unknow...

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Detalles Bibliográficos
Autores principales: Yamamoto, Kiyoko, Tsuzuki, Shinobu, Minami, Yosuke, Yamamoto, Yukiya, Abe, Akihiro, Ohshima, Koichi, Seto, Masao, Naoe, Tomoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787010/
https://www.ncbi.nlm.nih.gov/pubmed/24098673
http://dx.doi.org/10.1371/journal.pone.0074864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787010/
https://www.ncbi.nlm.nih.gov/pubmed/24098673
http://dx.doi.org/10.1371/journal.pone.0074864

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