Small Angle X-Ray Scattering Studies of Mitochondrial Glutaminase C Reveal Extended Flexible Regions, and Link Oligomeric State with Enzyme Activity

Glutaminase C is a key metabolic enzyme, which is unregulated in many cancer systems and believed to play a central role in the Warburg effect, whereby cancer cells undergo changes to an altered metabolic profile. A long-standing hypothesis links enzymatic activity to the protein oligomeric state, h...

Descripción completa

Detalles Bibliográficos
Autores principales: Møller, Magda, Nielsen, Søren S., Ramachandran, Sekar, Li, Yuxing, Tria, Giancarlo, Streicher, Werner, Petoukhov, Maxim V., Cerione, Richard A., Gillilan, Richard E., Vestergaard, Bente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787022/
https://www.ncbi.nlm.nih.gov/pubmed/24098668
http://dx.doi.org/10.1371/journal.pone.0074783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787022/
https://www.ncbi.nlm.nih.gov/pubmed/24098668
http://dx.doi.org/10.1371/journal.pone.0074783

Ejemplares similares