Relaxin Protects Rat Lungs from Ischemia-Reperfusion Injury via Inducible NO Synthase: Role of ERK-1/2, PI3K, and Forkhead Transcription Factor FKHRL1

INTRODUCTION: Early allograft dysfunction following lung transplantation is mainly an ischemia/reperfusion (IR) injury. We showed that relaxin-2 (relaxin) exerts a protective effect in lung IR, attributable to decreases in endothelin-1 (ET-1) production, leukocyte recruitment, and free radical gener...

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Detalles Bibliográficos
Autores principales: Alexiou, Konstantin, Wilbring, Manuel, Matschke, Klaus, Dschietzig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787055/
https://www.ncbi.nlm.nih.gov/pubmed/24098703
http://dx.doi.org/10.1371/journal.pone.0075592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787055/
https://www.ncbi.nlm.nih.gov/pubmed/24098703
http://dx.doi.org/10.1371/journal.pone.0075592

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