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Drosophila XBP1 Expression Reporter Marks Cells under Endoplasmic Reticulum Stress and with High Protein Secretory Load

Expression of genes in the endoplasmic reticulum (ER) beyond its protein folding capacity activates signaling pathways that are collectively referred to as the Unfolded Protein Response (UPR). A major branch of the UPR pathway is mediated by IRE1, an ER-tethered endonuclease. Upon ER stress-induced...

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Detalles Bibliográficos
Autores principales: Ryoo, Hyung Don, Li, Josepher, Kang, Min-Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787058/
https://www.ncbi.nlm.nih.gov/pubmed/24098723
http://dx.doi.org/10.1371/journal.pone.0075774