GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination

Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew, predisposes DNA sequences toward R-loop formation upon transcription. Previous work revealed that GC skew and R-loop formation associate with a core set of unmethylated CpG island (CGI) promoters in the human genome...

Descripción completa

Detalles Bibliográficos
Autores principales: Ginno, Paul A., Lim, Yoong Wearn, Lott, Paul L., Korf, Ian, Chédin, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787257/
https://www.ncbi.nlm.nih.gov/pubmed/23868195
http://dx.doi.org/10.1101/gr.158436.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787257/
https://www.ncbi.nlm.nih.gov/pubmed/23868195
http://dx.doi.org/10.1101/gr.158436.113

Ejemplares similares