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GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination
Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew, predisposes DNA sequences toward R-loop formation upon transcription. Previous work revealed that GC skew and R-loop formation associate with a core set of unmethylated CpG island (CGI) promoters in the human genome...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787257/ https://www.ncbi.nlm.nih.gov/pubmed/23868195 http://dx.doi.org/10.1101/gr.158436.113 |