De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements

Deep sequencing of mammalian DNA methylomes has uncovered a previously unpredicted number of discrete hypomethylated regions in intergenic space (iHMRs). Here, we combined whole-genome bisulfite sequencing data with extensive gene expression and chromatin-state data to define functional classes of i...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlesinger, Felix, Smith, Andrew D., Gingeras, Thomas R., Hannon, Gregory J., Hodges, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787258/
https://www.ncbi.nlm.nih.gov/pubmed/23811145
http://dx.doi.org/10.1101/gr.157271.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787258/
https://www.ncbi.nlm.nih.gov/pubmed/23811145
http://dx.doi.org/10.1101/gr.157271.113

Ejemplares similares