Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay

UPF1 is a DNA/RNA helicase with essential roles in nonsense-mediated mRNA decay (NMD) and embryonic development. How UPF1 regulates target abundance and the relationship between NMD and embryogenesis are not well understood. To explore how NMD shapes the embryonic transcriptome, we integrated genome...

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Detalles Bibliográficos
Autores principales: Hurt, Jessica A., Robertson, Alex D., Burge, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787261/
https://www.ncbi.nlm.nih.gov/pubmed/23766421
http://dx.doi.org/10.1101/gr.157354.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787261/
https://www.ncbi.nlm.nih.gov/pubmed/23766421
http://dx.doi.org/10.1101/gr.157354.113

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