Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes. Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates the Ras homolog Rap through an ill-defined no...

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Detalles Bibliográficos
Autores principales: Wang, Yuxiao, Pascoe, Heath G, Brautigam, Chad A, He, Huawei, Zhang, Xuewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787391/
https://www.ncbi.nlm.nih.gov/pubmed/24137545
http://dx.doi.org/10.7554/eLife.01279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787391/
https://www.ncbi.nlm.nih.gov/pubmed/24137545
http://dx.doi.org/10.7554/eLife.01279

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