Cargando…

TNFα Mediated IL-6 Secretion Is Regulated by JAK/STAT Pathway but Not by MEK Phosphorylation and AKT Phosphorylation in U266 Multiple Myeloma Cells

IL-6 and TNFα were significantly increased in the bone marrow aspirate samples of patients with active multiple myeloma (MM) compared to those of normal controls. Furthermore, MM patients with advanced aggressive disease had significantly higher levels of IL-6 and TNFα than those with MM in plateau...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Chansu, Oh, Jeong-In, Park, Juwon, Choi, Jee-Hye, Bae, Eun-Kyung, Lee, Hyun Jung, Jung, Woo June, Lee, Dong Soon, Ahn, Kwang-Sung, Yoon, Sung-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787550/ https://www.ncbi.nlm.nih.gov/pubmed/24151609 http://dx.doi.org/10.1155/2013/580135

Ejemplares similares

Establishment and characterization of bortezomib-resistant U266 cell line: Constitutive activation of NF-κB-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis
por: Park, Juwon, et al.
Publicado: (2014)

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells
por: Rhee, Yun-Hee, et al.
Publicado: (2012)

Frankincense and myrrh and their bioactive compounds ameliorate the multiple myeloma through regulation of metabolome profiling and JAK/STAT signaling pathway based on U266 cells
por: Gao, Rumeng, et al.
Publicado: (2020)

Depletion of Zinc Causes Osteoblast Apoptosis with Elevation of Leptin Secretion and Phosphorylation of JAK2/STAT3
por: Lee, Jennifer K., et al.
Publicado: (2022)

Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation
por: Timofeeva, Olga A., et al.
Publicado: (2012)

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation
por: Nitulescu, Ioana I., et al.
Publicado: (2017)

In vitro comparison of the cytotoxic effects of statins on U266 myeloma cell line
por: Terzi, Hatice, et al.
Publicado: (2019)

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation
por: Niu, Guo-Juan, et al.
Publicado: (2018)

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
por: Gough, Daniel J., et al.
Publicado: (2013)

Correction: The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
por: Gough, Daniel J., et al.
Publicado: (2013)

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade
por: Jung, Young Yun, et al.
Publicado: (2018)

Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation
por: Kim, Karam, et al.
Publicado: (2018)

Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL
por: Suzuki, Kazuhito, et al.
Publicado: (2016)

Baicalein Inhibits Proliferation of Myeloma U266 Cells by Downregulating IKZF1 and IKZF3
por: Liu, Xiao-Ping, et al.
Publicado: (2018)

Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells
por: Amit-Vazina, M, et al.
Publicado: (2005)

The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation
por: Wang, Tao, et al.
Publicado: (2021)

WRKY45 phosphorylation at threonine 266 acts negatively on WRKY45-dependent blast resistance in rice
por: Ueno, Yoshihisa, et al.
Publicado: (2017)

Somatostatin and opioid receptors do not regulate proliferation or apoptosis of the human multiple myeloma U266 cells
por: Kerros, Céline, et al.
Publicado: (2009)

Sandfly Fever Viruses Attenuate the Type I Interferon Response by Targeting the Phosphorylation of JAK-STAT Components
por: Moalem, Yarden, et al.
Publicado: (2022)

STAT2 phosphorylation and signaling
por: Steen, Håkan C, et al.
Publicado: (2013)

EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3
por: Concha-Benavente, Fernando, et al.
Publicado: (2013)

Novel Phosphorylations of IKKγ/NEMO
por: Lee, Sun Hwa, et al.
Publicado: (2012)

The antihypertension drug doxazosin suppresses JAK/STATs phosphorylation and enhances the effects of IFN-α/γ-induced apoptosis
por: Park, Mi Sun, et al.
Publicado: (2014)

Beep Test Does Not Induce Phosphorylation of Ras/MAPK- or JAK/STAT-Related Proteins in Peripheral Blood T Lymphocytes
por: Kostrzewa-Nowak, Dorota, et al.
Publicado: (2022)

The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma
por: Canovas Nunes, Sara, et al.
Publicado: (2018)

Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway
por: Huang, Wenqi, et al.
Publicado: (2021)

Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance
por: Shi, Lei, et al.
Publicado: (2010)

MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells
por: Yoo, Jung-Yoon, et al.
Publicado: (2017)

Silencing of augmenter of liver regeneration inhibited cell proliferation and triggered apoptosis in U266 human multiple myeloma cells
por: Zeng, H.Q., et al.
Publicado: (2017)

Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation
por: Chaudhari, Amol, et al.
Publicado: (2017)

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2
por: Yoshida, Takayuki, et al.
Publicado: (2012)

Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis
por: Procaccia, Shiri, et al.
Publicado: (2017)

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors
por: Lee, Matilda, et al.
Publicado: (2018)

Clinicopathologic implication of PD-L1 and phosphorylated STAT3 expression in diffuse large B cell lymphoma
por: Kwon, Hyun Jung, et al.
Publicado: (2018)

STAT3 phosphorylation in central leptin resistance
por: Liu, Huimin, et al.
Publicado: (2021)

SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection
por: Mo, Guodong, et al.
Publicado: (2021)

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2021)

SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1
por: Fung, Sin-Yee, et al.
Publicado: (2022)

Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
por: Zareifard, Amir, et al.
Publicado: (2023)

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
por: Slack-Davis, Jill K., et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_bp0bj4f09gs3ceg9ho8j908m6n