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miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer
GRP78, a major endoplasmic reticulum chaperone and signaling regulator, is commonly overexpressed in cancer. Moreover, induction of GRP78 by a variety of anti-cancer drugs, including histone deacetylase inhibitors, confers chemoresistance to cancer, thereby contributing to tumorigenesis. Thus, thera...
Autores principales: | Su, S-F, Chang, Y-W, Andreu-Vieyra, C, Fang, J Y, Yang, Z, Han, B, Lee, A S, Liang, G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787795/ https://www.ncbi.nlm.nih.gov/pubmed/23085757 http://dx.doi.org/10.1038/onc.2012.483 |
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