Single-Cell Analysis of Thymocyte Differentiation: Identification of Transcription Factor Interactions and a Major Stochastic Component in αβ-Lineage Commitment

T cell commitment and αβ/γδ lineage specification in the thymus involves interactions between many different genes. Characterization of these interactions thus requires a multiparameter analysis of individual thymocytes. We developed two efficient single-cell methods: (i) the quantitative evaluation...

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Detalles Bibliográficos
Autores principales: Boudil, Amine, Skhiri, Lamia, Candéias, Serge, Pasqualetto, Valérie, Legrand, Agnès, Bedora-Faure, Marie, Gautreau-Rolland, Laetitia, Rocha, Benedita, Ezine, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787938/
https://www.ncbi.nlm.nih.gov/pubmed/24098325
http://dx.doi.org/10.1371/journal.pone.0073098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787938/
https://www.ncbi.nlm.nih.gov/pubmed/24098325
http://dx.doi.org/10.1371/journal.pone.0073098

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