Cargando…

Single-Cell Analysis of Thymocyte Differentiation: Identification of Transcription Factor Interactions and a Major Stochastic Component in αβ-Lineage Commitment

T cell commitment and αβ/γδ lineage specification in the thymus involves interactions between many different genes. Characterization of these interactions thus requires a multiparameter analysis of individual thymocytes. We developed two efficient single-cell methods: (i) the quantitative evaluation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boudil, Amine, Skhiri, Lamia, Candéias, Serge, Pasqualetto, Valérie, Legrand, Agnès, Bedora-Faure, Marie, Gautreau-Rolland, Laetitia, Rocha, Benedita, Ezine, Sophie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787938/ https://www.ncbi.nlm.nih.gov/pubmed/24098325 http://dx.doi.org/10.1371/journal.pone.0073098

Ejemplares similares

Thymocytes may persist and differentiate without any input from bone marrow progenitors
por: Peaudecerf, Laetitia, et al.
Publicado: (2012)

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification
por: Wiede, Florian, et al.
Publicado: (2017)

Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
por: McCarron, Mark J., et al.
Publicado: (2019)

Human natural killer cell committed thymocytes and their relation to the T cell lineage
Publicado: (1993)

Stage-specific epigenetic gene silencing during thymocyte lineage commitment
por: Taniuchi, Ichiro
Publicado: (2013)

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling
por: Hagenbeek, Thijs J., et al.
Publicado: (2004)

Human Innate Mycobacterium tuberculosis–Reactive αβTCR(+) Thymocytes
por: Gold, Marielle C, et al.
Publicado: (2008)

T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis
por: Kreslavsky, Taras, et al.
Publicado: (2008)

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes
por: Carlyle, James R., et al.
Publicado: (1997)

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes
por: Gon, Stéphanie, et al.
Publicado: (2018)

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment
por: Ng, Kenneth KH, et al.
Publicado: (2018)

Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation
por: Besseyrias, Valerie, et al.
Publicado: (2007)

Transcriptional Regulation of Lineage Commitment - A Stochastic Model of Cell Fate Decisions
por: Teles, Jose, et al.
Publicado: (2013)

The Molecular Signature Underlying the Thymic Migration and Maturation of TCRαβ(+)CD4(+)CD8(-) Thymocytes
por: Teng, Fei, et al.
Publicado: (2011)

The Programmed Cell Death of an Immature Thymocyte Cell Line Transgenic for an αβ TCR and the c-myc Proto-Oncogene
por: Murdjeva, Marianna, et al.
Publicado: (1995)

Analyses of thymocyte commitment to regulatory T cell lineage in thymus of healthy subjects and patients with 22q11.2 deletion syndrome
por: Borna, Simon, et al.
Publicado: (2023)

Single-cell multiomic analysis of thymocyte development reveals drivers of CD4(+) T cell and CD8(+) T cell lineage commitment
por: Steier, Zoë, et al.
Publicado: (2023)

Interleukin-7 co-ordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection
por: Boudil, Amine, et al.
Publicado: (2015)

Emergent Dynamics of Thymocyte Development and Lineage Determination
por: Efroni, Sol, et al.
Publicado: (2007)

HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4(+)CD8(+) thymocytes for CD4-lineage commitment
por: Philips, Rachael Laura, et al.
Publicado: (2019)

Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset Commitment
por: Li, Xiao-Long, et al.
Publicado: (2013)

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity
por: Albert Basson, M., et al.
Publicado: (1998)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
por: Erman, Batu, et al.
Publicado: (2004)

Progressive Changes in CXCR4 Expression That Define Thymocyte Positive Selection Are Dispensable For Both Innate and Conventional αβT-cell Development
por: Lucas, Beth, et al.
Publicado: (2017)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping
por: Egawa, Takeshi, et al.
Publicado: (2008)

Coreceptor gene imprinting governs thymocyte lineage fate
por: Adoro, Stanley, et al.
Publicado: (2012)

Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
por: Guidos, Cynthia J.
Publicado: (2006)

Plasticity within the αβ(+)CD4(+) T-cell lineage: when, how and what for?
por: Coomes, Stephanie M., et al.
Publicado: (2013)

αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals
por: Aghaallaei, Narges, et al.
Publicado: (2021)

The Eδ enhancer controls the generation of CD4(−)CD8(−) αβTCR-expressing T cells that can give rise to different lineages of αβ T cells
por: Aifantis, Iannis, et al.
Publicado: (2006)

A Molecular Docking Study Reveals That Short Peptides Induce Conformational Changes in the Structure of Human Tubulin Isotypes αβI, αβII, αβIII and αβIV
por: Ebenezer, Oluwakemi, et al.
Publicado: (2023)

Epigenetic Control of Osteogenic Lineage Commitment
por: Montecino, Martin, et al.
Publicado: (2021)

Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
por: Garbe, Annette I., et al.
Publicado: (2006)

Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
por: Suzuki, Harumi, et al.
Publicado: (1997)

Impact on early outcomes and immune reconstitution of high-dose post-transplant cyclophosphamide vs anti-thymocyte globulin after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation
por: Retière, Christelle, et al.
Publicado: (2018)

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
por: Kojo, Satoshi, et al.
Publicado: (2017)

Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity
por: Carter, Jason A., et al.
Publicado: (2019)

Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential
por: Oh, Seungyoul, et al.
Publicado: (2023)

Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming
por: Shchuka, Virlana M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fg6an2qgn0qeaheritttjce382