Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

Augmentation of endogenous cannabinoid (eCB) signaling represents an emerging approach to the treatment of affective disorders. Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid to form prostaglandins, but also inactivates eCBs in vitro. However, the viability of COX-2 as a therapeutic target for...

Descripción completa

Detalles Bibliográficos
Autores principales: Hermanson, Daniel J., Hartley, Nolan D., Gamble-George, Joyonna, Brown, Naoko, Shonesy, Brian C., Kingsley, Phillip J., Colbran, Roger J., Reese, Jeffrey, Marnett, Lawrence J., Patel, Sachin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
https://www.ncbi.nlm.nih.gov/pubmed/23912944
http://dx.doi.org/10.1038/nn.3480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
https://www.ncbi.nlm.nih.gov/pubmed/23912944
http://dx.doi.org/10.1038/nn.3480

Ejemplares similares