Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

[Image: see text] Biologically active conformations of the IgG1 Fc homodimer are maintained by multiple hydrophobic interactions between the protein surface and the N-glycan. The Fc glycan modulates biological effector functions, including antibody-dependent cellular cytotoxicity (ADCC) which is med...

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Detalles Bibliográficos
Autores principales: Yu, Xiaojie, Baruah, Kavitha, Harvey, David J., Vasiljevic, Snezana, Alonzi, Dominic S., Song, Byeong-Doo, Higgins, Matthew K., Bowden, Thomas A., Scanlan, Christopher N., Crispin, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788586/
https://www.ncbi.nlm.nih.gov/pubmed/23745692
http://dx.doi.org/10.1021/ja4014375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788586/
https://www.ncbi.nlm.nih.gov/pubmed/23745692
http://dx.doi.org/10.1021/ja4014375

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