TRPV1 Potentiates TGFβ-Induction of Corneal Myofibroblast Development through an Oxidative Stress-Mediated p38-SMAD2 Signaling Loop

Injuring mouse corneas with alkali causes myofibroblast expression leading to tissue opacification. However, in transient receptor potential vanilloid 1 channel (TRPV1-/-) knockout mice healing results in transparency restoration. Since TGFβ is the primary inducer of the myofibroblast phenotype, we...

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Detalles Bibliográficos
Autores principales: Yang, Yuanquan, Wang, Zheng, Yang, Hua, Wang, Lingyan, Gillespie, Stephanie R., Wolosin, J. Mario, Bernstein, Audrey M., Reinach, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788725/
https://www.ncbi.nlm.nih.gov/pubmed/24098582
http://dx.doi.org/10.1371/journal.pone.0077300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788725/
https://www.ncbi.nlm.nih.gov/pubmed/24098582
http://dx.doi.org/10.1371/journal.pone.0077300

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