Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E(−/−) mice

Phosphatidylcholine-specific phospholipase C (PC-PLC) is a key factor in apoptosis and autophagy of vascular endothelial cells (VECs), and involved in atherosclerosis in apolipoprotein E(−/−) (apoE(−/−)) mice. But the endogenous regulators of PC-PLC are not known. We recently found a small chemical...

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Detalles Bibliográficos
Autores principales: Li, H, Huang, S, Wang, S, Zhao, J, Su, L, Zhao, B, Zhang, Y, Zhang, S, Miao, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789175/
https://www.ncbi.nlm.nih.gov/pubmed/24052074
http://dx.doi.org/10.1038/cddis.2013.317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789175/
https://www.ncbi.nlm.nih.gov/pubmed/24052074
http://dx.doi.org/10.1038/cddis.2013.317

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