Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

Evasion of apoptosis, for example, by inhibitor of apoptosis (IAP) proteins, contributes to treatment resistance and poor outcome in acute myeloid leukemia (AML). Here we identify a novel synergistic interaction between the small-molecule second mitochondria-derived activator of caspases (Smac) mime...

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Detalles Bibliográficos
Autores principales: Steinhart, L, Belz, K, Fulda, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789178/
https://www.ncbi.nlm.nih.gov/pubmed/24030154
http://dx.doi.org/10.1038/cddis.2013.320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789178/
https://www.ncbi.nlm.nih.gov/pubmed/24030154
http://dx.doi.org/10.1038/cddis.2013.320

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