PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis

Reduced expression and activity of the proapoptotic, double-stranded RNA-dependent protein kinase, PKR (protein kinase R) is observed in breast, lung and various leukemias, suggesting that loss of PKR potentiates transformation. Now we report that decreased PKR activity inhibits chemotherapy-induced...

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Detalles Bibliográficos
Autores principales: Cheng, X, Bennett, R L, Liu, X, Byrne, M, Stratford May, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789206/
https://www.ncbi.nlm.nih.gov/pubmed/24013665
http://dx.doi.org/10.1038/bcj.2013.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789206/
https://www.ncbi.nlm.nih.gov/pubmed/24013665
http://dx.doi.org/10.1038/bcj.2013.42

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