LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts with LRRK2. An in vitro kinase assay ex...

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Detalles Bibliográficos
Autores principales: Yun, Hye Jin, Park, Joohyun, Ho, Dong Hwan, Kim, Heyjung, Kim, Cy-Hyun, Oh, Hakjin, Ga, Inhwa, Seo, Hyemyung, Chang, Sunghoe, Son, Ilhong, Seol, Wongi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789260/
https://www.ncbi.nlm.nih.gov/pubmed/23949442
http://dx.doi.org/10.1038/emm.2013.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789260/
https://www.ncbi.nlm.nih.gov/pubmed/23949442
http://dx.doi.org/10.1038/emm.2013.68

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