Identification and Characterization of Enhancer-Blocking Insulators to Reduce Retroviral Vector Genotoxicity

The chromatin insulator cHS4 can reduce silencing chromosomal position effects and genotoxicity associated with integrating viral vectors. However, the fully active version of this element can also reduce vector titers and is only partially effective. In order to identify alternatives to cHS4, we de...

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Detalles Bibliográficos
Autores principales: Groth, Amy C., Liu, Mingdong, Wang, Hao, Lovelett, Emilie, Emery, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789682/
https://www.ncbi.nlm.nih.gov/pubmed/24098520
http://dx.doi.org/10.1371/journal.pone.0076528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789682/
https://www.ncbi.nlm.nih.gov/pubmed/24098520
http://dx.doi.org/10.1371/journal.pone.0076528

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