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Identification and Characterization of Enhancer-Blocking Insulators to Reduce Retroviral Vector Genotoxicity
The chromatin insulator cHS4 can reduce silencing chromosomal position effects and genotoxicity associated with integrating viral vectors. However, the fully active version of this element can also reduce vector titers and is only partially effective. In order to identify alternatives to cHS4, we de...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789682/ https://www.ncbi.nlm.nih.gov/pubmed/24098520 http://dx.doi.org/10.1371/journal.pone.0076528 |