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How Changes in Extracellular Matrix Mechanics and Gene Expression Variability Might Combine to Drive Cancer Progression
Changes in extracellular matrix (ECM) structure or mechanics can actively drive cancer progression; however, the underlying mechanism remains unknown. Here we explore whether this process could be mediated by changes in cell shape that lead to increases in genetic noise, given that both factors have...
Autores principales: | Werfel, Justin, Krause, Silva, Bischof, Ashley G., Mannix, Robert J., Tobin, Heather, Bar-Yam, Yaneer, Bellin, Robert M., Ingber, Donald E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789713/ https://www.ncbi.nlm.nih.gov/pubmed/24098430 http://dx.doi.org/10.1371/journal.pone.0076122 |
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